[CAS NO. 1609563-71-4]  (1R,2R)-2-PCCA hydrochloride

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PRODUCTS SPECIFICATIONS [1609563-71-4]

Catalog
HY-100013A1
Brand
MCE
CAS
1609563-71-4

DESCRIPTION [1609563-71-4]

Overview

MDL-
Molecular Weight528.56
Molecular FormulaC30H39Cl2N3O
SMILESCCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay.


IC50 & Target

EC50: 3 nM (GPR88 receptor) [1] , 603 nM (GPR88 receptor, in GPR88-22F cells) [2]


In Vitro

(1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC 50 of 3 nM in cell-free assay, and 603 nM in cell assay [1] [2] . (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC 50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)


Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 94.60 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8919 mL 9.4597 mL 18.9193 mL
5 mM 0.3784 mL 1.8919 mL 3.7839 mL
10 mM 0.1892 mL 0.9460 mL 1.8919 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

* All of the co-solvents are available by MCE.