[CAS NO. 1610610-48-4] KDU731
PRODUCTS SPECIFICATIONS [1610610-48-4]
DESCRIPTION [1610610-48-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 396.40 |
| Molecular Formula | C22H16N6O2 |
| SMILES | O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4 |
Summary
IC50 & Target
|
PI4K |
In Vivo
KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against
Cryptosporidium
in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding
[2]
.
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts [1] |
| Dosage: | 7 or 10 mg/kg |
| Administration: | Orally administration; 7 or 10 mg/kg; 16 days |
| Result: | Resulted in significant reduction of oocyst shedding. |
| Animal Model: | Neonatal calves with 5 x 10 7 oocysts [1] |
| Dosage: | 5 mg/kg |
| Administration: | Orally administration; 5 mg/kg; every 12 hours for 7 days |
| Result: | Resulted in significant reduction of oocyst shedding in treated calves in their stool. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 83.33 mg/mL ( 210.22 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5227 mL | 12.6135 mL | 25.2270 mL |
| 5 mM | 0.5045 mL | 2.5227 mL | 5.0454 mL |
| 10 mM | 0.2523 mL | 1.2614 mL | 2.5227 mL |
References