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[CAS NO. 1613710-01-2] ARN-3236
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-120856 |
| Brand: | MCE |
| CAS: | 1613710-01-2 |
Overview
| MDL | MFCD31813721 |
|---|---|
| Molecular Weight | 336.41 |
| Molecular Formula | C19H16N2O2S |
| SMILES | COC1=CC=C(C2=CNC3=NC=CC(C4=CSC=C4)=C32)C(OC)=C1 |
3 Publications Citing Use of MCE
Summary
IC50 & Target
|
SIK2 <1 nM (IC 50 ) |
SIK1 21.63 nM (IC 50 ) |
SIK3 6.63 nM (IC 50 ) |
In Vitro
ARN-3236 inhibits SIK2 activity with an IC
50
<1 nM
[2]
.
ARN-3236 inhibits cell growth and increases NSC 125973 sensitivity in ovarian cancer cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [2]
| Cell Line: | HEY and A2780 human ovarian cancer cell lines. |
| Concentration: | 0-10 μM. |
| Incubation Time: | 24 hours. |
| Result: | Inhibited SIK2 activity with an IC 50 <1 nM. |
In Vivo
ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | SKOv3ip-bearing mice and OVCAR8-bearing mice [2] . |
| Dosage: | 60 mg/kg. |
| Administration: | Orally once daily for 3 weeks (SKOv3ip-bearing mice) and 4 weeks (OVCAR8-bearing mice). |
| Result: | Sensitized ovarian cancer to NSC 125973. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 297.26 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9726 mL | 14.8628 mL | 29.7256 mL |
| 5 mM | 0.5945 mL | 2.9726 mL | 5.9451 mL |
| 10 mM | 0.2973 mL | 1.4863 mL | 2.9726 mL |
References
- [1] Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21.
- [2] Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.
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