[CAS NO. 1613710-01-2] ARN-3236

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1613710-01-2]

Catalog

HY-120856

Brand

MCE

CAS

1613710-01-2

DESCRIPTION [1613710-01-2]

Overview

MDL	MFCD31813721
Molecular Weight	336.41
Molecular Formula	C19H16N2O2S
SMILES	COC1=CC=C(C2=CNC3=NC=CC(C4=CSC=C4)=C32)C(OC)=C1

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2) , with IC ₅₀ s of <1 nM, 21.63 nM and 6.63 nM for SIK2 , SIK1 and SIK3 , respectively. Has anti-cancer activity ^[1] ^[2] .

IC50 & Target

SIK2

<1 nM (IC ₅₀ )

SIK1

21.63 nM (IC ₅₀ )

SIK3

6.63 nM (IC ₅₀ )

In Vitro

ARN-3236 inhibits SIK2 activity with an IC ₅₀ <1 nM ^[2] .
ARN-3236 inhibits cell growth and increases NSC 125973 sensitivity in ovarian cancer cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:	HEY and A2780 human ovarian cancer cell lines.
Concentration:	0-10 μM.
Incubation Time:	24 hours.
Result:	Inhibited SIK2 activity with an IC ₅₀ <1 nM.

In Vivo

ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SKOv3ip-bearing mice and OVCAR8-bearing mice ^[2] .
Dosage:	60 mg/kg.
Administration:	Orally once daily for 3 weeks (SKOv3ip-bearing mice) and 4 weeks (OVCAR8-bearing mice).
Result:	Sensitized ovarian cancer to NSC 125973.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 297.26 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9726 mL	14.8628 mL	29.7256 mL
5 mM	0.5945 mL	2.9726 mL	5.9451 mL
10 mM	0.2973 mL	1.4863 mL	2.9726 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.17 mg/mL (6.45 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.17 mg/mL (6.45 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.17 mg/mL (6.45 mM); Clear solution

* All of the co-solvents are available by MCE.