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[CAS NO. 1616385-51-3] Bezuclastinib
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-145557 |
| Brand: | MCE |
| CAS: | 1616385-51-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 331.37 |
| Molecular Formula | C19H17N5O |
| SMILES | O=C(C1=NNC(C)=C1C)NC2=CN=C3NC(C4=CC=CC=C4)=CC3=C2 |
Summary
IC50 & Target
|
c-Kit <1 μM (IC 50 ) |
c-kit D816V <1 μM (IC 50 ) |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02401815 | Cogent Biosciences, Inc.|Plexxikon |
Gastrointestinal Stromal Tumors
|
March 6, 2015 | Phase 1|Phase 2 |
| NCT05208047 | Cogent Biosciences, Inc. |
Advanced Gastrointestinal Stromal Tumors|Metastatic Cancer
|
April 14, 2022 | Phase 3 |
| NCT05186753 | Cogent Biosciences, Inc. |
SSM|Mastocytosis, Indolent|Mastocytosis, Systemic|Mastocytosis
|
October 26, 2021 | Phase 2 |
| NCT04996875 | Cogent Biosciences, Inc. |
Advanced Systemic Mastocytosis (AdvSM)|SM With an Associated Hematologic Neoplasm (SM-AHN)|Mast Cell Leukemia (MCL)|Aggressive Systemic Mastocytosis (ASM)
|
November 9, 2021 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 80 mg/mL ( 241.42 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0178 mL | 15.0889 mL | 30.1777 mL |
| 5 mM | 0.6036 mL | 3.0178 mL | 6.0355 mL |
| 10 mM | 0.3018 mL | 1.5089 mL | 3.0178 mL |
References
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