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[CAS NO. 1624117-53-8] XY1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19714 |
| Brand: | MCE |
| CAS: | 1624117-53-8 |
Overview
| MDL | MFCD28397755 |
|---|---|
| Molecular Weight | 297.35 |
| Molecular Formula | C17H19N3O2 |
| SMILES | O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=CC=CC3=C2 |
1 Publications Citing Use of MCE
Summary
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), but XY1 is completely inactive. Target: PRMT3 XY1 is a close analogue of SGC707, is completely inactive againstPRMT3 at concentrations as high as 100 μM. XY1 contains a naphthyl group replacing the isoquinoline group, lacks the key hydrogen bond with T466. The naphthyl ring of XY1 could act as a weak hydrogen-bond acceptor, but this should come with a substantial enthalpic penalty. The more than 1000-fold potency loss of XY1 compared with SGC707 supports this analysis. It is unclear whether other factors such as electronic effects also contributed to the potency loss of XY1 compared with SGC707. SGC707 and XY1 are a pair of excellent tools for the biomedical community to further elucidate biological functions and disease associations of PRMT3 .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04230629 | Medical University of Vienna |
Age Related Cataracts
|
March 15, 2021 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 67.5 mg/mL ( 227.01 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3630 mL | 16.8152 mL | 33.6304 mL |
| 5 mM | 0.6726 mL | 3.3630 mL | 6.7261 mL |
| 10 mM | 0.3363 mL | 1.6815 mL | 3.3630 mL |
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