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[CAS NO. 1627729-62-7] MLK-IN-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-111351 |
| Brand: | MCE |
| CAS: | 1627729-62-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 432.49 |
| Molecular Formula | C23H20N4O3S |
| SMILES | COC1=C2C(C=C(C3=CN=C4C=CC(NC5=CC=C(OC)C(OC)=C5)=NN43)S2)=CC=C1 |
Summary
MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1 [1] .
In Vitro
MLK-IN-1 (100 nM; pre-treatment 20 mins HIV-1 Tat) promotes continued axonogenesis in the presence of Tat-activated microglia and protects against effects of HIV-Tat in vitro
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 144.51 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3122 mL | 11.5610 mL | 23.1219 mL |
| 5 mM | 0.4624 mL | 2.3122 mL | 4.6244 mL |
| 10 mM | 0.2312 mL | 1.1561 mL | 2.3122 mL |
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