[CAS NO. 1628606-05-2]  Vimseltinib

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PRODUCTS SPECIFICATIONS [1628606-05-2]

Catalog
HY-136256
Brand
MCE
CAS
1628606-05-2

DESCRIPTION [1628606-05-2]

Overview

MDLMFCD32858282
Molecular Weight431.49
Molecular FormulaC23H25N7O2
SMILESO=C1N(C)C(NC(C)C)=NC=C1C2=NC(C)=C(OC3=CC(C4=CN(C)N=C4)=NC=C3)C=C2

For research use only. We do not sell to patients.

Summary

Vimseltinib (DCC-3014) is a c-FMS ( CSF-IR ) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC 50 s of <0.01 μM and 0.1-1 μM, respectively [1] .


IC50 & Target

IC50: <0.01 μM (c-FMS/CSF-IR), 0.1-1 μM (c-Kit) [1]


In Vitro

Vimseltinib is a c-FMS (CSF-IR) and c-Kit dual inhibitor with anti-cancer and anti-proliferative activities [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT04242238 Memorial Sloan Kettering Cancer Center
Sarcoma|Advanced Sarcoma|High Grade Sarcoma|Leiomyosarcoma|Undifferentiated Pleomorphic Sarcoma|Myxofibrosarcoma|Dedifferentiated Liposarcoma
January 22, 2020 Phase 1
NCT03069469 Deciphera Pharmaceuticals LLC
Advanced Malignant Neoplasm|Pigmented Villonodular Synovitis|Giant Cell Tumor of Tendon Sheath|Tenosynovial Giant Cell Tumor|Tenosynovial Giant Cell Tumor, Diffuse
February 16, 2017 Phase 1|Phase 2
NCT05059262 Deciphera Pharmaceuticals LLC
Tenosynovial Giant Cell Tumor|Pigmented Villonodular Synovitis|Giant Cell Tumor of Tendon Sheath|Tenosynovial Giant Cell Tumor, Diffuse|Tenosynovial Giant Cell Tumor, Localized
October 14, 2021 Phase 3

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 115.88 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3176 mL 11.5878 mL 23.1755 mL
5 mM 0.4635 mL 2.3176 mL 4.6351 mL
10 mM 0.2318 mL 1.1588 mL 2.3176 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 3.5 mg/mL (8.11 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.5 mg/mL (8.11 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 3.5 mg/mL (8.11 mM); Clear solution

* All of the co-solvents are available by MCE.