[CAS NO. 1643125-32-9] SAFit1
PRODUCTS SPECIFICATIONS [1643125-32-9]
DESCRIPTION [1643125-32-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 747.87 |
| Molecular Formula | C42H53NO11 |
| SMILES | O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(O)=O)=CC=C2)CCC3=CC(OC)=C(OC)C=C3)=O)[C@@H](C4CCCCC4)C5=CC(OC)=C(OC)C(OC)=C5 |
Summary
IC50 & Target
Ki: 4±0.3 nM (FKBP51), >50000 nM (FKBP52) [1]
In Vitro
SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 300 mg/mL ( 401.14 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3371 mL | 6.6857 mL | 13.3713 mL |
| 5 mM | 0.2674 mL | 1.3371 mL | 2.6743 mL |
| 10 mM | 0.1337 mL | 0.6686 mL | 1.3371 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (2.78 mM); Clear solution
References
- [1] Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7.
- [2] Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62(1):116-128.