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[CAS NO. 1681056-61-0] OSMI-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-119738 |
| Brand: | MCE |
| CAS: | 1681056-61-0 |
Overview
| MDL | MFCD30187585 |
|---|---|
| Molecular Weight | 563.64 |
| Molecular Formula | C28H25N3O6S2 |
| SMILES | O=C(N(CC1=CC=CS1)CC2=CC=CO2)[C@H](NS(C3=CC(C=C4)=C(C=C3)NC4=O)(=O)=O)C5=CC=CC=C5OC |
3 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 2.7 μM (O-GlcNAc transferase) [1]
In Vitro
OSMI-1 (50 μM; 24 hours; CHO cells) treatment decreases the viability by about 50% after 24 hours
[1]
.
OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment reduces global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner. OSMI-1 inhibits OGT activity in cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | CHO cells |
| Concentration: | 50 μM |
| Incubation Time: | 24 hours |
| Result: | Viability decreased by about 50% after 24 hours. |
Western Blot Analysis [1]
| Cell Line: | CHO cells |
| Concentration: | 10 μM, 25 μM, 50 μM, 100 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced global OGlcNAcylation in a dose-dependent manner. |
In Vivo
Mammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC 50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 177.42 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7742 mL | 8.8709 mL | 17.7418 mL |
| 5 mM | 0.3548 mL | 1.7742 mL | 3.5484 mL |
| 10 mM | 0.1774 mL | 0.8871 mL | 1.7742 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.69 mM); Clear solution
References
Synonyms
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