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[CAS NO. 1700637-55-3] CD38inhibitor1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-123999 |
| Brand: | MCE |
| CAS: | 1700637-55-3 |
Overview
| MDL | MFCD32062812 |
|---|---|
| Molecular Weight | 413.53 |
| Molecular Formula | C22H27N3O3S |
| SMILES | O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1 |
5 Publications Citing Use of MCE
Summary
CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC 50 s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38 [1] .
In Vivo
CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Diet induced obese (DIO) C57Bl6 mice [1] |
| Dosage: | 30 mg/kg |
| Administration: | Orally once |
| Result: | NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 60.46 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4182 mL | 12.0910 mL | 24.1820 mL |
| 5 mM | 0.4836 mL | 2.4182 mL | 4.8364 mL |
| 10 mM | 0.2418 mL | 1.2091 mL | 2.4182 mL |
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