[CAS NO. 1700637-55-3] CD38inhibitor1

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PRODUCTS SPECIFICATIONS [1700637-55-3]

Catalog

HY-123999

Brand

MCE

CAS

1700637-55-3

MDL	MFCD32062812
Molecular Weight	413.53
Molecular Formula	C22H27N3O3S
SMILES	O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1

For research use only. We do not sell to patients.

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC ₅₀ s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38 ^[1] .

IC50: 7.3 nM (hCD38), 1.9 nM (mouse CD38) ^[1]
Ki: 0.3 nM (WT hCD38) ^[1]

CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diet induced obese (DIO) C57Bl6 mice ^[1]
Dosage:	30 mg/kg
Administration:	Orally once
Result:	NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 25 mg/mL ( 60.46 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (6.05 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.05 mM); Clear solution

* All of the co-solvents are available by MCE.