[CAS NO. 170277-31-3]  Infliximab

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PRODUCTS SPECIFICATIONS [170277-31-3]

Catalog
HY-P9970
Brand
MCE
CAS
170277-31-3

DESCRIPTION [170277-31-3]

Overview

MDL-
Molecular Weight-
Molecular FormulaUnspecified
SMILES[Avakine]

For research use only. We do not sell to patients.


Summary

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α . Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [1] [2] .


In Vitro

TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α +/+ ) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00606346 Janssen Biotech, Inc.
Crohn´s Disease|Ulcerative Colitis|Indeterminate Colitis|Inflammatory Bowel Diseases
May 31, 2007
NCT02332356 Tokyo Medical and Dental University
Crohn Disease
September 2014 Phase 3
NCT04178850 Genor Biopharma Co., Ltd.
Rheumatoid Arthritis
October 13, 2017 Phase 3

Appearance

Solid


Storage

Please store the product under the recommended conditions in the Certificate of Analysis.



Synonyms

Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain), disulfide with human-mouse monoclonal cA2 light chain, dimer
Infliximab
Avakine
Remicade