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[CAS NO. 170569-86-5] SC-236
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W010983 |
| Brand: | MCE |
| CAS: | 170569-86-5 |
Overview
| MDL | MFCD00941297 |
|---|---|
| Molecular Weight | 401.79 |
| Molecular Formula | C16H11ClF3N3O2S |
| SMILES | O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O |
Summary
IC50 & Target
|
COX-2 10 nM (IC 50 ) |
COX-1 17.8 μM (IC 50 ) |
In Vitro
SC-236 (15 μM, 30 min) suppresses the side effects of NSAIDs and prevented inflammation in vECs subjected to ALSS
[1]
.
SC-236 significantly induces PPARγ expression in HSCs and acted as a potent PPARγ agonist in a luciferase-reporter trans-activation assay
[2]
.
SC-236 strongly inhibits, in a time- and concentration-dependent manner, macrophage
viability
[2]
.
SC-236, either alone or in combination with 15d-PGJ2, induced a marked pro-apoptotic effect in HSCs in culture
[2]
.
SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | vECs. |
| Concentration: | 15 μM |
| Incubation Time: | 30 min. |
| Result: | Showd significant reduction in COX-2 level and increase in IκBα level, thus preventing ALSS-induced NFκB activation and inflammation in vECs. |
Western Blot Analysis [2]
| Cell Line: | COS 7 cells. |
| Concentration: | 3 and 10 μM. |
| Incubation Time: | 18 h (combined with 15d-PGJ 2 ). |
| Result: | Acted in a concentration-dependent manner as a PPARγ agonist. |
In Vivo
SC-236 (6 mg/kg, gavage) exhibits anti-fibrotic properties in CCl4- treated animals
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Seventy-six male adult Wistar rats weighing 200-220 g (CCl 4 -treated) [2] . |
| Dosage: | 6 mg/kg. |
| Administration: | Orally, 3 times per week. |
| Result: |
A marked induction of COX-2 protein expression was detected by immunohistochemistry in the liver of CCl4-treated rats.
Significantly reduced the degree of liver fibrosis. Dramatically suppressed α-SMA expression in CCl4-treated rats. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 248.89 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4889 mL | 12.4443 mL | 24.8886 mL |
| 5 mM | 0.4978 mL | 2.4889 mL | 4.9777 mL |
| 10 mM | 0.2489 mL | 1.2444 mL | 2.4889 mL |
References
- [1] Shao-Yu Fang, et al. Reduction in MicroRNA-4488 Expression Induces NFκB Translocation in Venous Endothelial Cells Under Arterial Flow. Cardiovasc Drugs Ther. 2020 Sep 9.
- [2] Anna Planagumà, et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. FASEB J. 2005 Jul;19(9):1120-2.
- [3] Benjamin Chun-Yu Wong, et al. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Gastroenterology. 2004 Jan;126(1):136-47.
- [4] Su-Jin Kim, et al. The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model. Life Sci. 2007 Aug 23;81(11):863-72.
- [5] T D Penning, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem. 1997
Synonyms
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