[CAS NO. 1715934-43-2]  MI 14

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PRODUCTS SPECIFICATIONS [1715934-43-2]

Catalog
HY-110248
Brand
MCE
CAS
1715934-43-2

DESCRIPTION [1715934-43-2]

Overview

MDL-
Molecular Weight450.94
Molecular FormulaC19H23ClN6O3S
SMILESO=C(C)NCCNC1=CC(Cl)=NN2C1=NC(C)=C2C3=CC(S(=O)(N(C)C)=O)=CC=C3

For research use only. We do not sell to patients.

Summary

MI 14 is a selective PI4KIIIβ inhibitor with IC 50 s of 54 nM, >100 μM, >100 μM for PI4KIIIβ , PI4KIIIα , PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a [1] .


IC50 & Target

PI4KIIIβ

54 nM (IC 50 )

PI4KIIIα

>100 μM (IC 50 )

PI4KIIα

>100 μM (IC 50 )


In Vitro

MI 14 (compound 36t) has antiviral activity against HCV 1b (EC 50 =0.087 µM), CVB3 (EC 50 =0.145 µM), HRVM (EC 50 =1.03 µM), HVC 2a (EC 50 =10.6 µM) in HeLa cells [1] .
MI 14 has no inhibition on phosphatidylinositol 3-kinases (PI3Ka, PI3Kb, PI3Kd and PI3Kg) with IC 50 s up to 10 µM [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Please store the product under the recommended conditions in the Certificate of Analysis.