[CAS NO. 171674-89-8] Nitidanin
PRODUCTS SPECIFICATIONS [171674-89-8]
DESCRIPTION [171674-89-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 404.41 |
| Molecular Formula | C21H24O8 |
| SMILES | OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3 |
Summary
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC 50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum , respectively. Nitidanin can be used for the research of malaria and virus infection [1] [2] .
In Vitro
Nitidanin shows inhibitory effects to D6 and W2 clones of
Plasmodium falciparum
with IC
50
values of 21.2 and 18.4 μM, respectively
[1]
.
Nitidanin shows noncytotoxic effects to human oral epidermoid carcinoma (KB) cells with an EC
50
value ＞99 μM
[1]
.
Nitidanin shows low cytotoxic effect to human hepatoma Huh7.5.1 cells with an CC
50
value of 464.4 μM
[2]
.
Nitidanin (0-250 μM; 5 hours) shows anti-HCV activity with an IC
50
value of 200 μM
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50.
- [2] Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637.