[CAS NO. 173352-39-1] Fabomotizolehydrochloride
PRODUCTS SPECIFICATIONS [173352-39-1]
DESCRIPTION [173352-39-1]
Overview
| MDL | MFCD28167801 |
|---|---|
| Molecular Weight | 343.87 |
| Molecular Formula | C15H22ClN3O2S |
| SMILES | CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1.Cl |
Summary
Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic drug. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.
In Vitro
Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 290.81 mM ; Need ultrasonic)
DMSO : ≥ 44 mg/mL ( 127.96 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9081 mL | 14.5404 mL | 29.0808 mL |
| 5 mM | 0.5816 mL | 2.9081 mL | 5.8162 mL |
| 10 mM | 0.2908 mL | 1.4540 mL | 2.9081 mL |
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1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (145.40 mM); Clear solution; Need ultrasonic
References