[CAS NO. 173352-39-1]  Fabomotizolehydrochloride

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PRODUCTS SPECIFICATIONS [173352-39-1]

Catalog
HY-14895A
Brand
MCE
CAS
173352-39-1

DESCRIPTION [173352-39-1]

Overview

MDLMFCD28167801
Molecular Weight343.87
Molecular FormulaC15H22ClN3O2S
SMILESCCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1.Cl

For research use only. We do not sell to patients.

Summary

Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic drug. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.


In Vitro

Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

H 2 O : 100 mg/mL ( 290.81 mM ; Need ultrasonic)

DMSO : ≥ 44 mg/mL ( 127.96 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9081 mL 14.5404 mL 29.0808 mL
5 mM 0.5816 mL 2.9081 mL 5.8162 mL
10 mM 0.2908 mL 1.4540 mL 2.9081 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 50 mg/mL (145.40 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.