[CAS NO. 173952-44-8] SYM2206

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PRODUCTS SPECIFICATIONS [173952-44-8]

Catalog

HY-18689

Brand

MCE

CAS

173952-44-8

DESCRIPTION [173952-44-8]

Overview

MDL	-
Molecular Weight	366.41
Molecular Formula	C20H22N4O3
SMILES	O=C(N1N=C(C2=CC=C(N)C=C2)C3=C(C=C4C(OCO4)=C3)C1C)NCCC

For research use only. We do not sell to patients.

Summary

SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC ₅₀ of 1.6 μM. SYM2206 blocks Na _v 1.6-mediated persistent currents ^[1] ^[2] .

IC50 & Target

AMPA Receptor

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 272.92 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7292 mL	13.6459 mL	27.2918 mL
5 mM	0.5458 mL	2.7292 mL	5.4584 mL
10 mM	0.2729 mL	1.3646 mL	2.7292 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (7.51 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (7.51 mM); Clear solution

* All of the co-solvents are available by MCE.