[CAS NO. 174022-42-5] Bevirimat

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PRODUCTS SPECIFICATIONS [174022-42-5]

Catalog

HY-N0842

Brand

MCE

CAS

174022-42-5

DESCRIPTION [174022-42-5]

Overview

MDL	-
Molecular Weight	584.83
Molecular Formula	C36H56O6
SMILES	OC([C@]1(CC[C@H]2C(C)=C)[C@@]2([H])[C@](CC[C@@]3([H])[C@]4(CC[C@]5([H])[C@@]3(CC[C@H](OC(CC(C)(C)C(O)=O)=O)C5(C)C)C)C)([H])[C@@]4(C)CC1)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Int J Antimicrob Agents. 2019 Dec;54(6):814-819.

Summary

Bevirimat (PA-457; MPC-4326; YK FH312) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01026727	Myrexis Inc.	HIV Infections	November 2009	Phase 2
NCT00967187	Myrexis Inc.	HIV Infections	May 2008	Phase 2
NCT01097070	Myrexis Inc.	HIV-1 Infection	November 2008	Phase 2
NCT00511368	Myrexis Inc.	HIV Infections	April 2006	Phase 2

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL ( 85.49 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7099 mL	8.5495 mL	17.0990 mL
5 mM	0.3420 mL	1.7099 mL	3.4198 mL
10 mM	0.1710 mL	0.8549 mL	1.7099 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.27 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (4.27 mM); Suspended solution; Need ultrasonic and warming
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Lup-20(29)-en-28-oic acid, 3-(3-carboxy-3-methyl-1-oxobutoxy)-, (3β)-

(3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)lup-20(29)-en-28-oic acid

O-(3,3-Dimethylsuccinyl)betulinic acid

YK FH312

PA 457

3-O-(3′,3′-Dimethylsuccinyl)betulinic acid

Bevirimat

FH 11327

MP 4326