[CAS NO. 175556-12-4] Ro46-8443

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PRODUCTS SPECIFICATIONS [175556-12-4]

Catalog

HY-19431

Brand

MCE

CAS

175556-12-4

DESCRIPTION [175556-12-4]

Overview

MDL	MFCD00946586
Molecular Weight	609.69
Molecular Formula	C31H35N3O8S
SMILES	O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=CC=C(OC)C=C3)=NC(OC[C@H](O)CO)=C2OC4=CC=CC=C4OC)=O

For research use only. We do not sell to patients.

Summary

Ro 46-8443 is the first non-peptide endothelin ET _B receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ET _B ( IC ₅₀ : 34-69 nM) over ET _A receptors (IC ₅₀ : 6800 nM) ^[1] ^[2] .

IC50 & Target

ET _B

34-69 nM (IC ₅₀ )

ET _A

6800 nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 410.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6402 mL	8.2009 mL	16.4018 mL
5 mM	0.3280 mL	1.6402 mL	3.2804 mL
10 mM	0.1640 mL	0.8201 mL	1.6402 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.41 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (3.41 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.41 mM); Clear solution

* All of the co-solvents are available by MCE.