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[CAS NO. 1762-34-1] Abametapir
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W004546 |
| Brand: | MCE |
| CAS: | 1762-34-1 |
Overview
| MDL | MFCD01740554 |
|---|---|
| Molecular Weight | 184.24 |
| Molecular Formula | C12H12N2 |
| SMILES | CC1=CN=C(C2=NC=C(C)C=C2)C=C1 |
Summary
In Vitro
Abametapir is capable of chelating heavy metal ions, including iron, copper, and zinc, and is therefore able to interact with a range of targets within the insect that require metal co-factors for function, including metalloproteinases
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02060903 | Dr. Reddy´s Laboratories Limited|Accelovance|Syneos Health |
Head Lice Infestation
|
February 2014 | Phase 3 |
| NCT02062060 | Dr. Reddy´s Laboratories Limited|Accelovance|Syneos Health |
Head Lice Infestation
|
February 2014 | Phase 3 |
| NCT02061813 | Dr. Reddy´s Laboratories Limited |
Head Lice
|
January 2014 | Phase 1 |
| NCT02097485 | Dr. Reddy´s Laboratories Limited |
Head Lice Infestation
|
May 2014 | Phase 2 |
| NCT02062073 | Dr. Reddy´s Laboratories Limited|TKL Research, Inc.|Accelovance |
Head Lice
|
January 2014 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL ( 135.69 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.4277 mL | 27.1385 mL | 54.2770 mL |
| 5 mM | 1.0855 mL | 5.4277 mL | 10.8554 mL |
| 10 mM | 0.5428 mL | 2.7139 mL | 5.4277 mL |
References
- [1] Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295.
- [2] Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan; 54(1): 167-172.
Synonyms
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