[CAS NO. 1791396-46-7] Masupirdine mesylate
PRODUCTS SPECIFICATIONS [1791396-46-7]
DESCRIPTION [1791396-46-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 670.61 |
| Molecular Formula | C23H32BrN3O9S3 |
| SMILES | CS(=O)(O)=O.O=S(N1C2=CC=C(OC)C=C2C(CN3CCN(C)CC3)=C1)(C(C=CC=C4)=C4Br)=O.CS(=O)(O)=O |
Summary
Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist ( K i of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease [1] .
IC50 & Target
|
5-HT 6 Receptor 2.04 nM (Ki) |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02580305 | Suven Life Sciences Limited |
Alzheimer´s Disease
|
September 2015 | Phase 2 |
| NCT03564964 | Suven Life Sciences Limited |
Alzheimer Disease|Dementia|Cognition Disorders
|
||
| NCT05397639 | Suven Life Sciences Limited |
Agitation|Alzheimer´s Type Dementia
|
November 1, 2022 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)