[CAS NO. 1798286-48-2]  Camrelizumab

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PRODUCTS SPECIFICATIONS [1798286-48-2]

Catalog
HY-P9971
Brand
MCE
CAS
1798286-48-2

DESCRIPTION [1798286-48-2]

Overview

MDL-
Molecular Weight-
Molecular Formula-
SMILES[Camrelizumab]

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1 . Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC 50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al [1] [2] .


IC50 & Target

IC50: 0.70 nM ( PD-1/PD-L1 interaction) [1]


In Vitro

In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC 50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC 50 of 0.38 nM [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Camrelizumab (3 mg/kg) combines with apatinib (200 and 100 mg/kg) inhibits the tumor inhibition rates reached 63.1% and 87.3%, respectively in human PD-1 transgenic mice [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT03603756 Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophageal Squamous Cell Carcinoma
July 31, 2018 Phase 2
NCT05387512 Affiliated Hospital of Nantong University|The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Lung Cancer
January 12, 2022
NCT05313282 Sun Yat-sen University|Jiangsu HengRui Medicine Co., Ltd.
C-staged Hepatocellular Carcinoma in BCLC Classification
June 15, 2022 Phase 3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.