[CAS NO. 18000-24-3] 7-Chlorokynurenic acid
PRODUCTS SPECIFICATIONS [18000-24-3]
DESCRIPTION [18000-24-3]
Overview
| MDL | MFCD00674924 |
|---|---|
| Molecular Weight | 223.61 |
| Molecular Formula | C10H6ClNO3 |
| SMILES | O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O |
Summary
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor ( IC 50 =0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a K i of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery [1] [2] .
IC50 & Target
In Vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 16.67 mg/mL ( 74.55 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 4.47 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.4721 mL | 22.3604 mL | 44.7207 mL |
| 5 mM | 0.8944 mL | 4.4721 mL | 8.9441 mL |
| 10 mM | 0.4472 mL | 2.2360 mL | 4.4721 mL |
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1.
References
- [1] Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
- [2] Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
- [3] Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.
Synonyms