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[CAS NO. 1801185-08-9] SR12418
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-148103 |
| Brand: | MCE |
| CAS: | 1801185-08-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 483.57 |
| Molecular Formula | C31H30FNO3 |
| SMILES | O=C(N1CC2=C(C=C(F)C=C2)C[C@H]1COC3=CC=C(OC(C)(C)C)C=C3)C4=C5C=CC=CC5=CC=C4 |
Summary
IC50 & Target
IC50: 68 nM (REV-ERBα) and 119 nM (REV-ERBβ) [1]
In Vitro
SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells
[1]
.
SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | TH17 cells |
| Concentration: | 5 μM |
| Incubation Time: | 96 hours |
| Result: | Repressed TH17-mediated gene expression and Nfil3 . |
Cell Differentiation Assay [1]
| Cell Line: | Mouse CD4 + T cells |
| Concentration: | 5 and 10 μM |
| Incubation Time: | 4 days |
| Result: | Inhibited TH17 cell differentiation in a dose-dependent manner. |
In Vivo
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis
[1]
.
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6 mice inducing experimental autoimmune encephalomyelitis (EAE) [1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 50 mg/kg; twice a day |
| Result: |
Diminished the incidence of disease with approximately 20% mice developing disease.
Showed no overt signs of toxicity. |
| Animal Model: | PLP139-151-induced relapsing-remitting EAE (R-EAE) in SJL/J mice [1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization |
| Result: |
Resulted in a significant reduction in the relapse severity compared to the vehicle control.
Showed a significant decrease in the frequency and number of CD4 + and CD8 + effector cells (CD44 hi ). |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
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