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[CAS NO. 1801253-04-2] LSP-249
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-126378 |
| Brand: | MCE |
| CAS: | 1801253-04-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 431.92 |
| Molecular Formula | C24H22ClN5O |
| SMILES | O=C(C1=CC(CC2=CC=C3N=CC(Cl)=CC3=C2)=NC=C1)NCC4=C(C)C=C(N)N=C4C |
Summary
LSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC 50 less than 100 nM in cell [1] .
IC50 & Target
EC50：< 100 nM (kallikrein in cell) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 31.25 mg/mL ( 72.35 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3152 mL | 11.5762 mL | 23.1524 mL |
| 5 mM | 0.4630 mL | 2.3152 mL | 4.6305 mL |
| 10 mM | 0.2315 mL | 1.1576 mL | 2.3152 mL |
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