[CAS NO. 1801873-49-3] OICR-0547
PRODUCTS SPECIFICATIONS [1801873-49-3]
DESCRIPTION [1801873-49-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 542.55 |
| Molecular Formula | C28H29F3N4O4 |
| SMILES | O=C(C1=CNC(C=C1C(F)(F)F)=O)NC2=CC(C3=CC(CN4CCOCC4)=CC=C3)=CC=C2N5CCOCC5 |
Summary
In Vitro
OICR-0547 does not bind to WDR5
[1]
.
OICR-0547(0.1-100 μM) has no effect on cellular viability
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | K562 cells and Cebpa p30/p30 cells |
| Concentration: | 0.1-100 μM |
| Incubation Time: | |
| Result: | Induced non-selective toxicity at high doses in both cell types. |
In Vivo
OICR-0547 (i.v, i.p.; 3, 30 mg/kg) is a suitable negative control in NOD-SCID Mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | NOD-SCID Mice (female) [2] |
| Dosage: | 3, 30 mg/kg |
| Administration: | IV, IP |
| Result: | Served as a suitable negative control for biological experiments. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 184.31 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8431 mL | 9.2157 mL | 18.4315 mL |
| 5 mM | 0.3686 mL | 1.8431 mL | 3.6863 mL |
| 10 mM | 0.1843 mL | 0.9216 mL | 1.8431 mL |
References
- [1] Grebien F, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-578.
- [2] Matthäus Getlik, et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96.