[CAS NO. 1809010-52-3] Berotralstat dihydrochloride

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PRODUCTS SPECIFICATIONS [1809010-52-3]

Catalog

HY-109127A

Brand

MCE

CAS

1809010-52-3

DESCRIPTION [1809010-52-3]

Overview

MDL	-
Molecular Weight	635.48
Molecular Formula	C30H28Cl2F4N6O
SMILES	O=C(C1=CC(C(F)(F)F)=NN1C2=CC(CN)=CC=C2)NC3=CC([C@@H](C4=CC(C#N)=CC=C4)NCC5CC5)=CC=C3F.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

Summary

Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 120 mg/mL ( 188.83 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5736 mL	7.8681 mL	15.7361 mL
5 mM	0.3147 mL	1.5736 mL	3.1472 mL
10 mM	0.1574 mL	0.7868 mL	1.5736 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.2 mg/mL (1.89 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.2 mg/mL (1.89 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.2 mg/mL (1.89 mM); Clear solution

* All of the co-solvents are available by MCE.