[CAS NO. 18172-33-3] Cyclopiazonic acid

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PRODUCTS SPECIFICATIONS [18172-33-3]

Catalog

HY-N6771

Brand

MCE

CAS

18172-33-3

DESCRIPTION [18172-33-3]

Overview

MDL	-
Molecular Weight	336.38
Molecular Formula	C20H20N2O3
SMILES	O=C1C(C(C)=O)=C(O)[C@@]([C@]23[H])([H])N1C(C)(C)[C@]2([H])CC4=CC=CC5=C4C3=CN5

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Clin Invest. 2022 Apr 15;132(8):e149160.

Summary

Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus , is an inhibitor of endoplasmic reticulum calcium ATPase ( Ca ²⁺ ATPase ; SERCA) and a potent inducer of cell death in plants ^[1] .

Appearance

Solid

Source

Aspergillus flavus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 297.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9728 mL	14.8641 mL	29.7283 mL
5 mM	0.5946 mL	2.9728 mL	5.9457 mL
10 mM	0.2973 mL	1.4864 mL	2.9728 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Chalivendra SC, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact. 2017 May;30(5):361-373.

Synonyms

9H-Pyrrolo[1′,2′:2,3]isoindolo[4,5,6-cd]indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)-

9H-Pyrrolo[1′,2′:2,3]isoindolo[4,5,6-cd]indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aα,11aβ,11bα)-

(6aR,11aS,11bR)-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1′,2′:2,3]isoindolo[4,5,6-cd]indol-9-one

α-Cyclopiazonic acid

Cyclopiazonic acid

NSC 117181