[CAS NO. 1818868-23-3] HIV-1 inhibitor-52
PRODUCTS SPECIFICATIONS [1818868-23-3]
DESCRIPTION [1818868-23-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 770.13 |
| Molecular Formula | C46H72FNO5S |
| SMILES | O[C@]1(CC[C@@H](CC1)S(C)(=O)=O)CCN[C@]23[C@@]([C@@H](CC3)C(C)=C)([H])[C@]4([H])[C@@](CC2)([C@]5([C@]([C@@]6([C@@](C(C)(C(C7=CC[C@@](C(O)=O)(CF)CC7)=CC6)C)([H])CC5)C)([H])CC4)C)C |
Summary
IC50 & Target
|
HIV-1 (WT) 1.6 nM (EC 50 ) |
HIV-1 V370A 3.0 nM (EC 50 ) |
HIV-1 ΔV370 5.1 nM (EC 50 ) |
HIV-1 V362I/V370A 2.0 nM (EC 50 ) |
|
|
HIV-1 T332S/V362I/prR41G 6.4 nM (EC 50 ) |
HIV-1 A326T/V362I/V370A 4.3 nM (EC 50 ) |
HIV-1 R361K/V362I/L363M 4.5 nM (EC 50 ) |
||
In Vivo
HIV-1 inhibitor-52 (compound 26; 1 mg/kg; IV) has a T
1/2
of 4.2 hours, a CL of 3.5 mL/min·kg, and a V
ss
of 0.8 L/kg for rats
[1]
.
HIV-1 inhibitor-52 (5 mg/kg; po) has a C
max
of 0.83 μM and an AUC of 8.11 μM·h for rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male sprague-dawley rats [1] |
| Dosage: | 1 mg/kg |
| Administration: | IV |
| Result: | Had a T 1/2 of 4.2 hours, a CL of 3.5 mL/min•kg, and a V ss of 0.8 L/kg for rats. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.