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[CAS NO. 18201-65-5] Dichlorophenyl-ABA
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-113950 |
| Brand: | MCE |
| CAS: | 18201-65-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 282.12 |
| Molecular Formula | C13H9Cl2NO2 |
| SMILES | O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2 |
Summary
Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation , inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells [1] .
IC50 & Target
Transthyretin (TTR) amyloid fibril formation
In Vitro
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are
[1]
.
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 354.46 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5446 mL | 17.7230 mL | 35.4459 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL |
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