[CAS NO. 18201-65-5]  Dichlorophenyl-ABA

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PRODUCTS SPECIFICATIONS [18201-65-5]

Catalog
HY-113950
Brand
MCE
CAS
18201-65-5

DESCRIPTION [18201-65-5]

Overview

MDL-
Molecular Weight282.12
Molecular FormulaC13H9Cl2NO2
SMILESO=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

For research use only. We do not sell to patients.

Summary

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation , inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells [1] .


IC50 & Target

Transthyretin (TTR) amyloid fibril formation


In Vitro

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are [1] .
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 354.46 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5446 mL 17.7230 mL 35.4459 mL
5 mM 0.7089 mL 3.5446 mL 7.0892 mL
10 mM 0.3545 mL 1.7723 mL 3.5446 mL
* Please refer to the solubility information to select the appropriate solvent.