[CAS NO. 1820934-93-7] GlyT1Inhibitor1
PRODUCTS SPECIFICATIONS [1820934-93-7]
DESCRIPTION [1820934-93-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 387.43 |
| Molecular Formula | C22H21N5O2 |
| SMILES | CC(C)OC1=C(C(N2CC3=CN(C4=CC(C)=NC=C4)N=C3C2)=O)C=C(C#N)C=C1 |
Summary
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC 50 of 38 nM for rGlyT1 [1] . Antipsychotic activity [1] .
IC50 & Target
|
rGlyT1 38 nM (IC 50 ) |
In Vivo
GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 64.53 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5811 mL | 12.9056 mL | 25.8111 mL |
| 5 mM | 0.5162 mL | 2.5811 mL | 5.1622 mL |
| 10 mM | 0.2581 mL | 1.2906 mL | 2.5811 mL |