[CAS NO. 182621-58-5] (S)-Osanetant

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PRODUCTS SPECIFICATIONS [182621-58-5]

Catalog

HY-14551B

Brand

MCE

CAS

182621-58-5

DESCRIPTION [182621-58-5]

Overview

MDL	-
Molecular Weight	606.62
Molecular Formula	C35H41Cl2N3O2
SMILES	O=C(N1C[C@](CCCN2CCC(N(C(C)=O)C)(C3=CC=CC=C3)CC2)(C4=CC=C(Cl)C(Cl)=C4)CCC1)C5=CC=CC=C5

For research use only. We do not sell to patients.

Summary

(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 70 mg/mL ( 115.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6485 mL	8.2424 mL	16.4848 mL
5 mM	0.3297 mL	1.6485 mL	3.2970 mL
10 mM	0.1648 mL	0.8242 mL	1.6485 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Salomé N, et al. Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Pharmacol Biochem Behav. 2006 Apr;83(4):533-9.