[CAS NO. 1832578-30-9] MLT-748
PRODUCTS SPECIFICATIONS [1832578-30-9]
DESCRIPTION [1832578-30-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 492.32 |
| Molecular Formula | C19H19Cl2N9O3 |
| SMILES | O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@@H](OC)[C@H](OC)C)N4C(N=C3)=CC(Cl)=N4 |
2 Publications Citing Use of MCE
Summary
In Vitro
MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (K
d
, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (K
d
, 42 nM)
[1]
.
MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC
50
of 69 nM
[1]
.
MLT-748 (2 µM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1
mut/mut
patient immortalized B cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis
| Cell Line: | MALT1 mut/mut patient immortalized B cells |
| Concentration: | 2 µM |
| Incubation Time: | 24 hours |
| Result: | Increased NF-κB signaling phosphorylation of both p65 and IκBα as early as 5 min after stimulation with PMA and ionomycin. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 200 mg/mL ( 406.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0312 mL | 10.1560 mL | 20.3120 mL |
| 5 mM | 0.4062 mL | 2.0312 mL | 4.0624 mL |
| 10 mM | 0.2031 mL | 1.0156 mL | 2.0312 mL |
-
1.
Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.22 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.22 mM); Clear solution