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[CAS NO. 1848959-11-4] TAS4464hydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-128586A |
| Brand: | MCE |
| CAS: | 1848959-11-4 |
Overview
| MDL | MFCD32067968 |
|---|---|
| Molecular Weight | 542.97 |
| Molecular Formula | C21H24ClFN6O6S |
| SMILES | NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[C@@H]4O[C@H](CNS(=O)(N)=O)[C@@H](O)[C@H]4O.Cl |
2 Publications Citing Use of MCE
Summary
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) , with an IC 50 of 0.955 nM [1] .
IC50 & Target
IC50：0.955 nM (NAE) [1]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02978235 | Taiho Oncology, Inc. |
Multiple Myeloma|NonHodgkin Lymphoma
|
March 1, 2017 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 83.33 mg/mL ( 153.47 mM ; Need ultrasonic)
H 2 O : 5 mg/mL ( 9.21 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8417 mL | 9.2086 mL | 18.4172 mL |
| 5 mM | 0.3683 mL | 1.8417 mL | 3.6834 mL |
| 10 mM | 0.1842 mL | 0.9209 mL | 1.8417 mL |
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