[CAS NO. 186452-09-5] GPI-1046

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PRODUCTS SPECIFICATIONS [186452-09-5]

Catalog

HY-124619

Brand

MCE

CAS

186452-09-5

DESCRIPTION [186452-09-5]

Overview

MDL	MFCD00953146
Molecular Weight	360.45
Molecular Formula	C20H28N2O4
SMILES	O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2

For research use only. We do not sell to patients.

Summary

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models ^[1] . GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models ^[2] . GPI-1046 improves HIV -associated injury of peripheral nerves ^[3] .

IC50 & Target

GLT1

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 277.43 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7743 mL	13.8715 mL	27.7431 mL
5 mM	0.5549 mL	2.7743 mL	5.5486 mL
10 mM	0.2774 mL	1.3872 mL	2.7743 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

* All of the co-solvents are available by MCE.