[CAS NO. 1876463-35-2] WH-4-025

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PRODUCTS SPECIFICATIONS [1876463-35-2]

Catalog

HY-138001

Brand

MCE

CAS

1876463-35-2

MDL	-
Molecular Weight	741.76
Molecular Formula	C39H38F3N7O5
SMILES	O=C(OC1=CC(C(NC2=CC(C(F)(F)F)=CC=C2)=O)=CC=C1C)N(C3=NC(NC4=CC=C(N(CC5)CCN5C)C=C4)=NC=C3)C(C=CC(OC)=C6)=C6OC

For research use only. We do not sell to patients.

WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2) ^[1] .

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 125 mg/mL ( 168.52 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (2.80 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (2.80 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (2.80 mM); Clear solution

* All of the co-solvents are available by MCE.