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[CAS NO. 187870-78-6] Rimeporide
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19273 |
| Brand: | MCE |
| CAS: | 187870-78-6 |
Overview
| MDL | MFCD30533663 |
|---|---|
| Molecular Weight | 333.38 |
| Molecular Formula | C11H15N3O5S2 |
| SMILES | O=C(NC(N)=N)C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C |
Summary
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na + /H + exchanger (NHE-1).
IC50 & Target
NHE1 [1]
In Vitro
Blocking NHE-1 activity has been shown to decrease intracellular Na + and Ca 2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02710591 | EspeRare Foundation |
Muscular Dystrophy, Duchenne
|
March 2016 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20 mg/mL ( 59.99 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9996 mL | 14.9979 mL | 29.9958 mL |
| 5 mM | 0.5999 mL | 2.9996 mL | 5.9992 mL |
| 10 mM | 0.3000 mL | 1.4998 mL | 2.9996 mL |
Synonyms
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