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[CAS NO. 1881233-39-1] PI4KIIIbeta-IN-10
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100198 |
| Brand: | MCE |
| CAS: | 1881233-39-1 |
Overview
| MDL | MFCD30187514 |
|---|---|
| Molecular Weight | 475.58 |
| Molecular Formula | C22H25N3O5S2 |
| SMILES | COC1=CC=C(C2=C(C)N=C(NC(C(C)(C)C)=O)S2)C=C1S(NC3=CC=C(O)C=C3)(=O)=O |
9 Publications Citing Use of MCE
- [1]Nat Immunol. 2022 Nov 28.
- [2]J Extracell Vesicles. 2022 Jun;11(6):e12233.
- [3]Nat Chem Biol. 2022 Jul 4.
- [4]EMBO J. 2022 Nov 21;e112677.
- [5]Autophagy. 2019 Jul;15(7):1214-1233.
- [6]Cell Rep. 2022 Dec 20;41(12):111868.
- [7]Elife. 2017 Nov 1;6:e29388.
- [8]J Cell Sci. 2019 Apr 3;132(7):jcs220061.
- [9]Patent. US20220273624A1.
Summary
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC 50 of 3.6 nM.
IC50 & Target
IC50: 3.6 nM (PI4KIIIβ), 720 nM (PI3Kδ), ~1 µM (PI3KC2γ), ~10 µM (PI3Kα), ~3 µM (PI4KIIIα) [1]
In Vitro
PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC 50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 262.84 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1027 mL | 10.5135 mL | 21.0270 mL |
| 5 mM | 0.4205 mL | 2.1027 mL | 4.2054 mL |
| 10 mM | 0.2103 mL | 1.0513 mL | 2.1027 mL |
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