[CAS NO. 1881233-39-1] PI4KIIIbeta-IN-10

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PRODUCTS SPECIFICATIONS [1881233-39-1]

Catalog

HY-100198

Brand

MCE

CAS

1881233-39-1

DESCRIPTION [1881233-39-1]

Overview

MDL	MFCD30187514
Molecular Weight	475.58
Molecular Formula	C22H25N3O5S2
SMILES	COC1=CC=C(C2=C(C)N=C(NC(C(C)(C)C)=O)S2)C=C1S(NC3=CC=C(O)C=C3)(=O)=O

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC ₅₀ of 3.6 nM.

IC50 & Target

IC50: 3.6 nM (PI4KIIIβ), 720 nM (PI3Kδ), ~1 µM (PI3KC2γ), ~10 µM (PI3Kα), ~3 µM (PI4KIIIα) ^[1]

In Vitro

PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC ₅₀ ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 262.84 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1027 mL	10.5135 mL	21.0270 mL
5 mM	0.4205 mL	2.1027 mL	4.2054 mL
10 mM	0.2103 mL	1.0513 mL	2.1027 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

* All of the co-solvents are available by MCE.