[CAS NO. 1883528-69-5] Ly93

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PRODUCTS SPECIFICATIONS [1883528-69-5]

Catalog

HY-114307

Brand

MCE

CAS

1883528-69-5

DESCRIPTION [1883528-69-5]

Overview

MDL	-
Molecular Weight	332.40
Molecular Formula	C21H20N2O2
SMILES	O=C(NC1=CC=CN=C1)C2=CC=CC=C2OCC3=C(CC)C=CC=C3

For research use only. We do not sell to patients.

Summary

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC ₅₀ of 91 nM ^[1] .

In Vivo

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice ^[1] .
Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice ^[1] .
Dosage:	100 mg/kg.
Administration:	I.G. (gavage) once daily for 7 days.
Result:	Significantly decreased the plasma SM levels compared with vehicle group.

Animal Model:	ApoE KO mice (eight-week-old) ^[1] .
Dosage:	12.5 or 40 mg/kg.
Administration:	I.G. (gavage) once daily.
Result:	The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 752.11 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0084 mL	15.0421 mL	30.0842 mL
5 mM	0.6017 mL	3.0084 mL	6.0168 mL
10 mM	0.3008 mL	1.5042 mL	3.0084 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.