[CAS NO. 188640-63-3] p-Ethynylphenylalaninehydrochloride

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PRODUCTS SPECIFICATIONS [188640-63-3]

Catalog

HY-23460A

Brand

MCE

CAS

188640-63-3

DESCRIPTION [188640-63-3]

Overview

MDL	MFCD20259693
Molecular Weight	225.67
Molecular Formula	C11H12ClNO2
SMILES	N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Mol Biol. 2022 Jul 2;167716.

Summary

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K _i of 32.6 μM ^[1] .

IC50 & Target

Ki: 32.6 μM (TPH) ^[1]

In Vitro

p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin ^[1] .
p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT ₁ , 5-HT ₂ , 5-HT ₄ , 5-HT ₅ , 5-HT ₆ , and 5-HT ₇ ) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue ^[1] .
p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (200 g) ^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection
Result:	Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 221.56 mM ; ultrasonic and warming and heat to 60°C)

H ₂ O : 12.5 mg/mL ( 55.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4312 mL	22.1562 mL	44.3125 mL
5 mM	0.8862 mL	4.4312 mL	8.8625 mL
10 mM	0.4431 mL	2.2156 mL	4.4312 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.08 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (11.08 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.08 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.

Synonyms

L-Phenylalanine, 4-ethynyl-, hydrochloride (1:1)

L-Phenylalanine, 4-ethynyl-, hydrochloride

4-Ethynyl-L-phenylalanine hydrochloride