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[CAS NO. 188640-63-3] p-Ethynylphenylalaninehydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-23460A |
| Brand: | MCE |
| CAS: | 188640-63-3 |
Overview
| MDL | MFCD20259693 |
|---|---|
| Molecular Weight | 225.67 |
| Molecular Formula | C11H12ClNO2 |
| SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl |
1 Publications Citing Use of MCE
Summary
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM [1] .
IC50 & Target
Ki: 32.6 μM (TPH) [1]
In Vitro
p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin
[1]
.
p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue
[1]
.
p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats (200 g) [1] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL ( 221.56 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : 12.5 mg/mL ( 55.39 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.4312 mL | 22.1562 mL | 44.3125 mL |
| 5 mM | 0.8862 mL | 4.4312 mL | 8.8625 mL |
| 10 mM | 0.4431 mL | 2.2156 mL | 4.4312 mL |
Synonyms
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