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[CAS NO. 189639-09-6] 9-Cyclopentyladeninemonomethanesulfonate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-116530 |
| Brand: | MCE |
| CAS: | 189639-09-6 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 299.35 |
| Molecular Formula | C11H17N5O3S |
| SMILES | NC1=C2N=CN(C3CCCC3)C2=NC=N1.CS(=O)(O)=O |
Summary
9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties [1] [2] .
In Vitro
9-Cyclopentyladenine monomethanesulfonate (200 μM, 30 min) inhibits the activation of cAMP response element binding protein (CREB) and completely blocks neurogenesis in PC12 cells
[1]
.
9-Cyclopentyladenine monomethanesulfonate (100 μM, 30min) attenuates the effect of relaxin on mechanical activity and prevents relaxin-induced hyperpolarization thereby being involved in the regulation of relaxin on ileal smooth muscle activity in female CD1 Swiss mice
[2]
.
9-Cyclopentyladenine monomethanesulfonate (100 μM, 6 hours) promotes restoration of the keratinocyte permeability barrier by inhibiting the synthesis of cAMP in male hairless mice
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 41.67 mg/mL ( 139.20 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3406 mL | 16.7029 mL | 33.4057 mL |
| 5 mM | 0.6681 mL | 3.3406 mL | 6.6811 mL |
| 10 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL |
References
- [1] Ulrike Riese，et al. Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways. FEBS Lett. 2004 Nov 19;577(3):455-9.
- [2] Eglantina Idrizaj，et al. Relaxin influences ileal muscular activity through a dual signaling pathway in mice. World J Gastroenterol. 2018 Feb 28;24(8):882-893.
- [3] Mitsuhiro Denda, et al. Association of cyclic adenosine monophosphate with permeability barrier homeostasis of murine skin. J Invest Dermatol. 2004 Jan;122(1):140-6.
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