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[CAS NO. 1902114-15-1] PC786
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-102038 |
| Brand: | MCE |
| CAS: | 1902114-15-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 715.83 |
| Molecular Formula | C41H38FN5O4S |
| SMILES | O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC(C)=CN=C5N6CC7(CCOCC7)C6)=O)C=C4)=O)CC2)NC8=C(C)C=CC=C8F |
Summary
In Vitro
PC786 demonstrates a potent and selective antiviral activity against laboratory-adapted or clinical isolates of RSV-A (IC 50 <0.09 to 0.71 nM) and RSV-B (IC 50 , 1.3 to 50.6 nM), which are determined by inhibition of cytopathic effects in HEp-2 cells without causing detectable cytotoxicity. PC786 inhibits RSV A2 activity, exhibiting an IC 50 and IC 90 of 0.50±0.0014 nM and 0.63±0.035 nM, respectively. PC786 inhibits RSV B WST activity, exhibiting an IC 50 and IC 90 of 27.3±0.77 nM and 57.1±3.87 nM, respectively. PC786 exhibits potent inhibition of cytopathic effect (CPE) induced by known RSV A clinical isolates (IC 50 , 0.14 to 3.2 nM). PC786 also exhibits potent inhibition of CPE induced by various low-passage-number clinical isolates of RSV A (IC 50 , 0.42 nM [median]) and RSV B (IC 50 , 17.5 nM [median]) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Once-daily treatment with PC786, on days-1 to 3, by either intratracheal (i.t.) or intranasal (i.n.) administration, is found to inhibit viral loads in the lungs of RSV A2-infected BALB/c mice. The viral load is below the level of detection when the drug is given at 2 mg/mL (40 μg/mouse [approximately 1.6 mg/kg of body weight] for i.t. treatment, or 80 μg/mouse [approximately 3.2 mg/kg] for i.n. treatment) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03236233 | Pulmocide Ltd |
Respiratory Syncytial Virus (RSV)
|
June 21, 2017 | Phase 1 |
| NCT03715023 | Pulmocide Ltd |
Respiratory Syncytial Virus Infections
|
November 5, 2018 | Phase 2 |
| NCT03382431 | Pulmocide Ltd |
Respiratory Syncytial Virus Infections
|
November 14, 2017 | Phase 1|Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 130 mg/mL ( 181.61 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3970 mL | 6.9849 mL | 13.9698 mL |
| 5 mM | 0.2794 mL | 1.3970 mL | 2.7940 mL |
| 10 mM | 0.1397 mL | 0.6985 mL | 1.3970 mL |
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