[CAS NO. 19057-67-1] Prosapogenin A

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PRODUCTS SPECIFICATIONS [19057-67-1]

Catalog

HY-N6940

Brand

MCE

CAS

19057-67-1

DESCRIPTION [19057-67-1]

Overview

MDL	-
Molecular Weight	722.90
Molecular Formula	C39H62O12
SMILES	C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O7)O)O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)CC6)=CC5)C)([H])CC2

For research use only. We do not sell to patients.

Summary

Prosapogenin A, a natural product from Veratrum , induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 138.33 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3833 mL	6.9166 mL	13.8332 mL
5 mM	0.2767 mL	1.3833 mL	2.7666 mL
10 mM	0.1383 mL	0.6917 mL	1.3833 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (3.46 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Wang TX, et al. Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncol Lett. 2013 Nov;6(5):1323-1328.

Synonyms

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-

Spirost-5-ene, 3β-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-, (25R)-

Spirostan, β-D-glucopyranoside deriv.

Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], β-D-glucopyranoside deriv.

(3β,25R)-Spirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Glucopyranoside, (25R)-spirost-5-en-3β-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-, β-D-

Prosapogenin A of dioscin

Prosapogenin A

Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside

Prosapogenin A, from Dioscoreatokoro

Prosapogenin D′₁

Ophiopogonin C'

Progenin III

Lilioglycoside D

Polyphyllin V

25(R)-Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside

Paris V

17-Deoxyparis VI

Saponin Ta

Paris saponin V