[CAS NO. 1917350-09-4] MDM2-p53-IN-16
PRODUCTS SPECIFICATIONS [1917350-09-4]
DESCRIPTION [1917350-09-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 539.62 |
| Molecular Formula | C32H33N3O5 |
| SMILES | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(OC)=O)=O)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=O |
Summary
In Vitro
MDM2-p53-IN-16 (0.01 nM-100 μM; 1 hour) dissociates MDM2-p53 interaction with an IC
50
value of 4.3 nM
[1]
.
MDM2-p53-IN-16 (1 µM; 8 hours) significantly increases the levels of p53 in GBM cells
[1]
.
MDM2-p53-IN-16 (1 µM; 6 hours) increases the mRNA levels of p53 target genes: MDM2, PUMA and p21 in U87MG cells
[1]
.
MDM2-p53-IN-16 binds with translocator protein (TSPO) with a K
i
value of 87.2 nM
[1]
.
MDM2-p53-IN-16 (1 µM; 24 hours) induces early and late apoptosis and cell cycle arrest of U87MG cells
[1]
.
MDM2-p53-IN-16 (1-10000 nM; 48 h) shows antiproliferative activities to U87MG and wild-type p53 U343MG cells with IC
50
values of 1.2 and 1.6 μM, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | U87MG, U343MG and T98G cell lines |
| Concentration: | 1-10000 nM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell proliferation of U87MG, U343MG and T98G cells. |
Apoptosis Analysis [1]
| Cell Line: | U87MG cell line |
| Concentration: | 1 µM |
| Incubation Time: | 24 hours |
| Result: | Induced cell apoptosis of U87MG cells. |
Cell Cycle Analysis [1]
| Cell Line: | U87MG, U343MG and T98G cell lines |
| Concentration: | 1-10000 nM |
| Incubation Time: | 48 hours |
| Result: | Induced cell cycle arrest progression in the G2/M-phase of U87MG cells. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.