[CAS NO. 19210-12-9] Harpagoside

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PRODUCTS SPECIFICATIONS [19210-12-9]

Catalog

HY-N0396

Brand

MCE

CAS

19210-12-9

DESCRIPTION [19210-12-9]

Overview

MDL	MFCD00017415
Molecular Weight	494.49
Molecular Formula	C24H30O11
SMILES	O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2OC=C[C@]3(O)[C@@]2([H])[C@@](C)(OC(/C=C/C4=CC=CC=C4)=O)C[C@H]3O)O[C@@H]1CO

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Cell Metab. 2022 Feb 7;34(3):424-440.e7.

Summary

Harpagoside is isolated from Harpagophytum procumbens . Harpagoside has inhibitory effects on COX-1 and COX-2 activity and inhibits NO production ^[1] .

IC50 & Target

COX-1

COX-2

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 126.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0223 mL	10.1114 mL	20.2229 mL
5 mM	0.4045 mL	2.0223 mL	4.0446 mL
10 mM	0.2022 mL	1.0111 mL	2.0223 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (12.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 6.25 mg/mL (12.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24(9):1365-9.

Synonyms

β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl

Harpagoside

β-D-Glucopyranoside, 1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(1-oxo-3-phenyl-2-propenyl)oxy]cyclopenta[c]pyran-1-yl, [1S-[1α,4aα,5α,7α(E),7aα]]-

β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1-yl

(1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-D-glucopyranoside

E-Harpagoside