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Catalog: | HY-132228 |
Brand: | MCE |
CAS: | 1929519-13-0 |
MDL | MFCD32858822 |
---|---|
Molecular Weight | 392.33 |
Molecular Formula | C18H15F3N4O3 |
SMILES | O=C(N[C@H](C1=CC=C(OC(F)(F)F)C=C1)C)CN2N=NC3=CC=CC=C3C2=O |
TAK-041 (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: | BALB/c mice [1] |
Dosage: | 0.03, 0.3, and 3 mg/kg |
Administration: | P.o. |
Result: | Dose-dependently improved the social behavior of BALB/c mice. |
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT02748694 | Neurocrine Biosciences|Takeda |
Healthy Volunteers|Schizophrenia
|
May 9, 2016 | Phase 1 |
NCT05165394 | Neurocrine Biosciences |
Anhedonia|Major Depressive Disorder
|
November 30, 2021 | Phase 2 |
NCT03319953 | Neurocrine Biosciences|Takeda |
Stable Schizophrenia
|
December 21, 2017 | Phase 2 |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 100 mg/mL ( 254.89 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.5489 mL | 12.7444 mL | 25.4887 mL |
5 mM | 0.5098 mL | 2.5489 mL | 5.0977 mL |
10 mM | 0.2549 mL | 1.2744 mL | 2.5489 mL |
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution
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