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[CAS NO. 1941211-99-9] LSN 3213128
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-107981 |
| Brand: | MCE |
| CAS: | 1941211-99-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 409.46 |
| Molecular Formula | C17H16FN3O4S2 |
| SMILES | O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[C@@H](O)C4)S3)=O)C(F)=C2 |
Summary
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase ( AICARFT ), with IC 50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity [1] .
IC50 & Target
IC50: 16 nM (AICARFT), 19 nM (AICARFT in cells) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 152.64 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4422 mL | 12.2112 mL | 24.4224 mL |
| 5 mM | 0.4884 mL | 2.4422 mL | 4.8845 mL |
| 10 mM | 0.2442 mL | 1.2211 mL | 2.4422 mL |
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