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[CAS NO. 195199-95-2] SB 258719
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-U00443 |
| Brand: | MCE |
| CAS: | 195199-95-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 338.51 |
| Molecular Formula | C18H30N2O2S |
| SMILES | O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O |
Summary
SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease [1] [2] [3] .
IC50 & Target
|
5-HT 7 Receptor 7.5 (pKi) |
In Vitro
SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Swiss Webster mice (20-25 g) [2] . |
| Dosage: | 5-20 mg/kg |
| Administration: | I.p. |
| Result: | Significantly attenuated the 5-CT-induced hypothermia. |
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 738.53 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9541 mL | 14.7706 mL | 29.5412 mL |
| 5 mM | 0.5908 mL | 2.9541 mL | 5.9082 mL |
| 10 mM | 0.2954 mL | 1.4771 mL | 2.9541 mL |
References
- [1] Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br J Pharmacol. 1998;124(6):1300-1306.
- [2] Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037.
- [3] Fatima S, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10(2):195-212.
Synonyms
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