[CAS NO. 195514-23-9] AP1867

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PRODUCTS SPECIFICATIONS [195514-23-9]

Catalog

HY-114434

Brand

MCE

CAS

195514-23-9

DESCRIPTION [195514-23-9]

Overview

MDL	-
Molecular Weight	693.78
Molecular Formula	C38H47NO11
SMILES	COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)=O)C4=CC=CC(OCC(O)=O)=C4)C=C1OC

For research use only. We do not sell to patients.

Summary

AP1867 is a synthetic FKBP12 ^F36V -directed ligand ^[1] .

IC50 & Target

FKBP ^[1]

In Vitro

AP1867 associates with wild-type FKBP (K _d = 67 nM) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 144.14 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4414 mL	7.2069 mL	14.4138 mL
5 mM	0.2883 mL	1.4414 mL	2.8828 mL
10 mM	0.1441 mL	0.7207 mL	1.4414 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.00 mM); Clear solution

* All of the co-solvents are available by MCE.