[CAS NO. 195822-23-2] LQZ-7I

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PRODUCTS SPECIFICATIONS [195822-23-2]

Catalog

HY-136538

Brand

MCE

CAS

195822-23-2

DESCRIPTION [195822-23-2]

Overview

MDL	MFCD00607076
Molecular Weight	348.35
Molecular Formula	C20H14F2N4
SMILES	FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1

For research use only. We do not sell to patients.

Summary

LQZ-7I is a survivin -targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors ^[1] .

IC50 & Target

Survivin ^[1]

In Vitro

LQZ-7I has improved cytotoxicity with IC ₅₀ s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7 ^[1] .
LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[1]

Cell Line:	PC-3 or C4-2 cells
Concentration:	10 µM
Incubation Time:	0-6 hours
Result:	Reduced the expression of survivin.

In Vivo

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old male NSG mice ^[1]
Dosage:	100 mg/kg; 200 µL vehicle (90% corn oil/10% DMSO)
Administration:	Oral gavage every other day for a total of ten treatments
Result:	Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 358.83 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8707 mL	14.3534 mL	28.7068 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.