[CAS NO. 19608-29-8] Clascoterone

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PRODUCTS SPECIFICATIONS [19608-29-8]

Catalog

HY-13331

Brand

MCE

CAS

19608-29-8

DESCRIPTION [19608-29-8]

Overview

MDL	-
Molecular Weight	402.52
Molecular Formula	C24H34O5
SMILES	O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4(C(CO)=O)OC(CC)=O)=C1

For research use only. We do not sell to patients.

Summary

Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.

IC50 & Target

Androgen Receptor ^[1] .

In Vivo

Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02608450	Cassiopea SpA	Acne Vulgaris	January 21, 2016	Phase 3
NCT01631474	Intrepid Therapeutics, Inc.	Acne Vulgaris	June 2012	Phase 2
NCT03665194	Cassiopea SpA	Healthy Volunteers	June 6, 2018	Phase 1
NCT02608476	Cassiopea SpA	Acne Vulgaris	November 16, 2015	Phase 3
NCT02682264	Cassiopea SpA	Acne Vulgaris	March 9, 2016	Phase 3
NCT02720627	Cassiopea SpA	Acne Vulgaris	October 28, 2016	Phase 2
NCT01831960	Intrepid Therapeutics, Inc.	Acne Vulgaris	April 2013	Phase 2
NCT02279823	Intrepid Therapeutics, Inc.	Androgenetic Alopecia	October 2014	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 248.43 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4843 mL	12.4217 mL	24.8435 mL
5 mM	0.4969 mL	2.4843 mL	4.9687 mL
10 mM	0.2484 mL	1.2422 mL	2.4843 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-

Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 17-propionate

21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione

Clascoterone

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